The Department of Health and UNAids data show substantial progress in preventing mother-to-child transmission of HIV since 2004. This resulted in a significant drop in child infections during this period. Progress has also been made over the past four years in the implementation of the national Prevention of Mother-to-Child Transmission programme that has enabled South Africa to reduce mother-to-child transmission of HIV from 8% to an estimated 2,7% for up to six weeks after birth. We are working towards zero transmission.